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Veröffentlichungen des Jahres 2010, Stand 22.6.2011



 Bücher 2010
1.
 Dresdner Symposium Hämatologie und Onkologie 2009, Ed: Ehninger, G. In: Colloquium Onkologie Vol. 9. Edited by: Ehninger, G., Freund, M., and Overkamp, F. München: Lukon Verlag, 2010. ISBN 978-3-933012-14-2; 188 Seiten.

2
 Update Hämatologie / Onkologie 2010, Eds: Petrasch, S. and Ehninger, G. In: Colloquium Onkologie Vol. 8. Edited by: Ehninger, G., Freund, M., and Overkamp, F. München: Lukon Verlag, 2010. IISBN: 978-3-933012-16-6; 672 Seiten.





Buchbeiträge 2010
1.
 Greiner J, Schmitt M. T cell therapy for patients targeting leukemia-associated antigens (LAAs) in haematological malignancies and after allogeneic stem cell transplantation. In: Spyridonidis A, Sakellari I. New Insights in Hematopoietic Cell Transplantation. Trivandrum, India: Research Signpost, 2010:247-54.
2
 Lampe H. Traditionelle Chinesische Medizin einschließlich Akupunktur. In: Holzhauer P, Gröber U. Checkliste Komplementäre Onkologie. Stuttgart: Hippokrates Verlag, 2010:198-208.



  Publikationen in Zeitschriften mit Impact-Punkten 2010 Punkte
1. Thiel E, Korfel A, Martus P, Kanz L, Griesinger F, Rauch M, Roth A, Hertenstein B, von Toll T, Hundsberger T, Mergenthaler HG, Leithauser M, Birnbaum T, Fischer L, Jahnke K, Herrlinger U, Plasswilm L, Nagele T, Pietsch T, Bamberg M, Weller M. High-dose methotrexate with or without whole brain radiotherapy for primary CNS lymphoma (G-PCNSL-SG-1): a phase 3, randomised, non-inferiority trial. Lancet Oncol. 2010;11:1036-47.
 14,470
2. Chen BA, Shan XY, Chen J, Wang F, Ding JH, Gao C, Zhao G, Wang XM, Xu WL, Gao F, Xia GH, Schmitt M. Study on reversal effect of nilotinib in combination with 5-BrTet on multidrug resistance of K562/A02 cell line. Zhonghua Xue Ye Xue Za Zhi 2010;31:385-8.
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3. Jiang J, Casalegno-Garduno R, Chen H, Schmitt A, Schmitt M, Maxwell CA. Multifunctional proteins bridge mitosis with motility and cancer with inflammation and arthritis. The Scientific World Journal 2010;10:1244-57.
 1,658
4. Casalegno-Garduno R, Schmitt A, Wang X, Xu X, Schmitt M. Targeted cellular immunotherapy for leukemia patients. Transfus Apher.Sci. 2010;43:207-10.
 0,938
5. Casalegno-Garduno R, Schmitt A, Wang X, Xu X, Schmitt M. Wilms' tumor 1 as a novel target for immunotherapy of leukemia. Transplant Proc. 2010;42:3309-11.
 0,994
6.
 Fritzsche C, Loebermann M, Lampe H, Reisinger EC. It began with a suspected abscess. Am.J Med. 2010;123:e9-e10.
 4,466
7. Wolkenhauer O, Auffray C, Baltrusch S, Bluthgen N, Byrne H, Cascante M, Ciliberto A, Dale T, Drasdo D, Fell D, Ferrell JE, Jr., Gallahan D, Gatenby R, Gunther U, Harms BD, Herzel H, Junghanss C, Kunz M, van L, I, Lenormand P, Levi F, Linnebacher M, Lowengrub J, Maini PK, Malik A, Rateitschak K, Sansom O, Schafer R, Schurrle K, Sers C, Schnell S, Shibata D, Tyson J, Vera J, White M, Zhivotovsky B, Jaster R. Systems biologists seek fuller integration of systems biology approaches in new cancer research programs. Cancer Research 2010;70:12-3.
 7,543
8. Sterenczak KA, Joetzke AE, Willenbrock S, Eberle N, Lange S, Junghanss C, Nolte I, Bullerdiek J, Simon D, Murua EH. High-mobility Group B1 (HMGB1) and Receptor for Advanced Glycation End-products (RAGE) Expression in Canine Lymphoma. Anticancer Res. 2010;30:5043-8.
 1,428
9. Landfried K, Bataille F, Rogler G, Brenmoehl J, Kosovac K, Wolff D, Hilgendorf I, Hahn J, Edinger M, Hoffmann P, Obermeier F, Schoelmerich J, Andreesen R, Holler E. Recipient NOD2/CARD15 status affects cellular infiltrates in human intestinal graft-versus-host disease. Clin Exp.Immunol. 2010;159:87-92.
 3,009
10. Greiner J, Schmitt A, Giannopoulos K, Rojewski MT, Gotz M, Funk I, Ringhoffer M, Bunjes D, Hofmann S, Ritter G, Dohner H, Schmitt M. High-dose RHAMM-R3 peptide vaccination for patients with acute myeloid leukemia, myelodysplastic syndrome and multiple myeloma. Haematologica 2010;95:1191-7.
 6,416
11. Fei F, Yu Y, Schmitt A, Rojewski MT, Chen B, Greiner J, Gotz M, Bunjes D, Schmitt M. Effects of nilotinib on regulatory T cells: the dose matters. Mol.Cancer 2010;9:22.
 4,160
12. Giannopoulos K, Dmoszynska A, Kowal M, Rolinski J, Gostick E, Price DA, Greiner J, Rojewski M, Stilgenbauer S, Dohner H, Schmitt M. Peptide vaccination elicits leukemia-associated antigen-specific cytotoxic CD8+ T-cell responses in patients with chronic lymphocytic leukemia. Leukemia 2010;24:798-805.
 8,296
13. Schneidawind D, Schmitt A, Wiesneth M, Mertens T, Bunjes D, Freund M, Schmitt M. Polyomavirus BK-specific CD8+ T cell responses in patients after allogeneic stem cell transplant. Leuk.Lymphoma.  2010;51:1055-62.
 2,397
14. Herzberg PY, Heussner P, Mumm FH, Horak M, Hilgendorf I, von Harsdorf S, Hemmati P, Rieger K, Greinix H, Freund M, Lee SJ, Holler E, Wolff D. Validation of the human activity profile questionnaire in patients after allogeneic hematopoietic stem cell transplantation. Biol.Blood Marrow Transplant. 2010;16:1707-17.
 3,149
15. Schult C, Dahlhaus M, Ruck S, Sawitzky M, Amoroso F, Lange S, Etro D, Glass A, Fuellen G, Boldt S, Wolkenhauer O, Neri LM, Freund M, Junghanss C. The multikinase inhibitor Sorafenib displays significant antiproliferative effects and induces apoptosis via caspase 3, 7 and PARP in B- and T-lymphoblastic cells. BMC Cancer. 2010;10:560.
 2,736
16. Freund M. Correspondence (letter to the editor): National foundation. Dtsch.Arztebl.Int. 2010;107:671-4.
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17.
 Leithauser M, Kahl C, Aepinus C, Prall F, Maruschke M, Riemer H, Wolff D, Jost K, Hilgendorf I, Freund M, Junghanss C. Invasive zygomycosis in patients with graft-versus-host disease after allogeneic stem cell transplantation. Transpl.Infect.Dis. 2010;12:251-7.
 2,063
18.
 Glass B, Ziepert M, Reiser M, Freund M, Trumper L, Metzner B, Feller A, Loeffler M, Pfreundschuh M, Schmitz N. High-dose therapy followed by autologous stem-cell transplantation with and without rituximab for primary treatment of high-risk diffuse large B-cell lymphoma. Annals of Oncology 2010;21:2255-61.
 5,647
19.
 Wang X, Schmitt A, Chen B, Xu X, Mani J, Linnebacher M, Freund M, Schmitt M. Streptamer-based selection of WT1-specific CD8(+) T cells for specific donor lymphocyte infusions. Exp.Hematol. 2010.
 3,106
20. Kahl C, Hirt C, Decker S, Glaser D, Rohde S, Jost K, Hilgendorf I, Respondek-Dryba E, Leithauser M, Junghanss C, Freund M. Multimodal therapy for localized spinal epidural follicular lymphoma. Onkologie 2010;33:381-4.
 1,234
21. Kahl C, Freund M. Peripheral blood alterations in a patient with infectious mononucleosis. Br.J Haematol. 2010;150:2.
 4,597
22. Casper J, Wolff D, Knauf W, Blau IW, Ruutu T, Volin L, Wandt H, Schafer-Eckart K, Holowiecki J, Giebel S, Aschan J, Zander AR, Kroger N, Hilgendorf I, Baumgart J, Mylius HA, Pichlmeier U, Freund M. Allogeneic hematopoietic stem-cell transplantation in patients with hematologic malignancies after dose-escalated treosulfan/fludarabine conditioning. J Clin Oncol. 2010;28:3344-51.
 17,793
23. Casalegno-Garduno R, Schmitt A, Yao J, Wang X, Xu X, Freund M, Schmitt M. Multimer technologies for detection and adoptive transfer of antigen-specific T cells. Cancer Immunol.Immunother. 2010;59:195-202.
 3,791
24. Gerber B, Freund M, Reimer T. Rezidiviertes Mammakarzinom: Therapiekonzepte zum Erhalt der Lebensqualität. Dt.Ärztebl. 2010;107:85-91.
 -
     
  Summe 97,451


Habilitation

Frau Dr. med. Anita Schmitt: Entwicklung, Charakterisierung und GMP-gerechte Anwendung von innovativen zellulären Therapien.

Promotion
Viktoria Rößler: Therapie der steroidrefraktären akuten Graft-versus-Host-Krankheit mit Daclizumab und Etanercept.

Abstrakts
  1. Elmaagacli, A. H., Lindemann, M., Opalka, B., Koldehoff, M., Gromke, T., Ottinger, H., Ross, S., Bauer, S., Hilgendorf, I., and Beelen, D. W. Cytomegalovirus increases incidence of acute GvHD and reduces the relapse risk for acute leukaemia after transplant: there is a virus-versus-leukaemia effect. EBMT 2010, Abstr. O234. (Abstract)

  2. Gökbuget, N., Brüggemann, M., Arnold, R., Bartram, C.-R., Fietkau, R., Freund, M., Ganser, A., Kneba, M., Lipp, T., Ludwig, W.-D., Maschmeyer, G., Messerer, D., Raff, T., Rieder, H., Serve, H., Thiel, E., and Hoelzer, D. Definition of molecular remission in adult acute lymphoblastic leukemia (ALL) based on minimal residual disease (MRD). Onkologie 33, Suppl. 6, Abs. V710. 2010. (Abstract)

  3. Hilgendorf, I., Mueller-Hilke, B., Kundt, G., Holler, E., Hoffmann, P., Edinger, M., Freund, M., and Wolff, D. Lymphocyte subsets in chronic Gvhd - a key role for B cells? ASH Annual Meeting Abstracts 116(21), 2311. 19-11-2010. (Abstract)

  4. Hilgendorf, I., Jilg, W., Einsele, H., Greinix, H., Halter, J., Freund, M., Lawitschka, A., Wolff, D., and Meisel, R. Vaccination of haematopoietic stem cell transplant recipients: Report from the International Consensus Conference on Clinical Practice in chronic
    GVHD. Onkologie 33, Suppl. 6, Abs. V123. 2010. (Abstract)

  5. Hilgendorf, I., Respondek-Dryba, E., Lampe, H., Wittke, C., Leithäuser, M., Junghanss, C., and Freund, M. Monthly treatment with romiplostin in a patient with severe aplastic anaemia and immune thrombocytopenia. Onkologie 33, Suppl. 6, Abs. P183. 2010. (Abstract)

  6. Hilgendorf, I., Loebermann, M., Borchert, K., Junghanss, C., Freund, M., and Schmitt, M. Tenofovir for the treatment of hepatitis B virus reactivation in patients with chronic GvHD. EBMT 2010, Abstr. P792. (Abstract)

  7. Jost, K., Leithäuser, M., Hilgendorf, I., Wittke, C., Borchert, K., Jeske, S., Heyne, U., Crusius, S., Junghanss, C., Freund, M., and Kahl, C. Meningoencephalitis and sepsis caused by Listeria monocytogenes after consumption of contaminated cheese in a patient with
    lymphoplasmacytic lymphoma. Onkologie 33, Suppl. 6, Abs. P240. 2010. (Abstract)

  8. Jost, K., Killian, D., Sekora, A., Escobar, H., Nolte, I., Kahl, C., Freund, M., and Junghanss, C. HMGB1 serum levels in patients with hematologic malignancies before and following chemotherapy. Onkologie 33, Suppl. 6, Abs. P917. 2010. (Abstract)

  9. Kahl, C., Sayer, H., Hinke, A., Pester, F., Freund, M., Casper, J., für die Ostdeutsche Studiengruppe Hämatologie und Onkologie (OSHO). Early versus late administration of pegfilgrastim after autologous hematopoietic stem cell transplantation. Onkologie 33, Suppl. 6, Abs. P567. 2010. (Abstract)

  10. Killian, D., Knueppel, A., Lange, S., Dunkelmann, S., Fitting, J., Willenbrock, S., Wefstaedt, P., Murua Escobar, H., Nolte, I., Barth, S., Sekora, A., Freund, M., and Junghanss, C. Migration of canine dendritic cells can be detected by radioactive-labelling and varies according to injection sites. EBMT 2010, Abstr. P901. (Abstract)

  11. Killian, D., Knueppel, A., Willenbrock, S., Murua Escobar, H., Heisterkamp, A., Lubatschowski, H., Nolte, I., Sekora, A., Freund, M., and Junghanss, C. Influence of high mobility group Box 1 on allogeneic immune responses. EBMT 2010, Abstr. P900. (Abstract)

  12. Knödler, M., Egerer, G., Freund, M., Kettner, E., Euckner, J., Stoll, C., Schmittel, A., and Keilholz, U. Safety and efficacy of nonpegylated liposomal doxorubicin plus ifosfamide versus conventional doxorubicin plus ifosfamide in locally advanced or
    metastatic soft tissue sarcoma: interim analysis of a randomized phase II trial. Onkologie 33, Suppl. 6, Abs. P594. 2010. (Abstract)

  13. Knueppel, A., Killian, D., Lange, S., Sekora, A., Freund, M., and Junghanss, C. Intra-bone marrow transplantation of allogeneic DLA-identical CD34 + cells allows successful engraftment in DLA-identical canine litters following non-myeloablative conditioning. EBMT 2010, Abstr. P897. (Abstract)

  14. Knueppel, A., Killian, D., Lange, S., Sekora, A., Freund, M., and Junghanss, C. Recovery of regulatory T-cells following non-myeloablative DLA-identical littermate allogeneic stem cell. EBMT 2010, Abstr. P896. (Abstract)

  15. Lampe, H. and Freund, M. Evidence-based complementary and alternative medicine (CAM) in oncology. Onkologie 33, Suppl. 6, Abs. V296. 2010. (Abstract)
    Lampe, H., Liu, J., Leithäuser, M., Lakner, V., Hildebrandt, G., Kraft, K., and Freund, M. Chinese Medicine after exhaustion of existing standard treatments. Onkologie 33, Suppl. 6, Abs. P262. 2010. (Abstract)

  16. Meyer, S., Kragl, B., Jost, K., Grosse-Thie, C., Borchert, K., Leithäuser, M., Kahl, C., and Junghanss, C. Obese acute myeloid leukemia patients have significantly longer leukopenia periods following high dose cytosine arabinoside containing
    chemotherapy at unreduced dose. Onkologie 33, Suppl. 6, Abs. P491. 2010. (Abstract)

  17. Niederwieser, D., Schueler, F., Hegenbart, U., Maschmeyer, G., Fischer, T., Junghanss, C., Wolf, H., Sayer, H. G., Kreibich, U., and Doelken, G. Improvement of leukemia-free survival (LFS) and reduction of relapse incidence by allogeneic stem cell transplantation (SCT) in elderly patients (pts) with AML irrespective of the FLT3-ITD and npm status except npm+/flt3(ITD)-. J Clin Oncol 28 (suppl)(15s), abstr 6505. 2010. (Abstract)

  18. Schmitt, A., Xu, X., Wang, X., Hilgendorf, I., Borchert, K., Freund, M., and Schmitt, M. WT1 and RHAMM specific CD8 +  T-cells can be isolated and purified by streptamers for adoptive transfer. EBMT 2010, Abstr. O362. (Abstract)

  19. Schmitt, M., Sayer, H. G., Hilgendorf, I., Treschl, A., Junghanss, C., Borchert, K., Königsmann, M., Casper, J., Freund, M., and Kahl, C. Conditioning with treosulfan and fludarabine for patients with refractory or relapsed non-Hodgkin lymphoma (NHL). Onkologie 33, Suppl. 6, Abs. P556. 2010. (Abstract)

  20. Schneidawind, D., Mani, J., Schmitt, A., Bunjes, D., Freund, M., and Schmitt, M. Polyomavirus-specific CD8+ T cell responses in patients after allogeneic stem cell transplantation. Onkologie 33, Suppl. 6, Abs. V124. 2010. (Abstract)

  21. Schneidawind, D., Schmitt, A., Bunjes, D., Freund, M., and Schmitt, M. Patients after allogeneic stem cell transplantation can generate polyomavirus-specific CD8 + T-cell responses. EBMT 2010, Abstr. P700. (Abstract)

  22. Schüler, F., Maschmeier, G., Fischer, T., Herold, M., Sayer, H. G., Wolf, H.-H., Kreibich, U, Hähling, D., Dölken, G., Junghanss, C., Grobe, N., Krahl, R., Lange, T., Al-Ali, H., Basara, N., Pönisch, W., and Niederwieser, D. Allogeneic stem cell transplantation reduces the relapse incidence in patients with AML and normal karyotype independently of the FLT3-ITD status. EBMT 2010, Abstr. O234. (Abstract)

  23. Schult, C., Fischer, K., Dahlhaus, M., Goetz, M., Lange, S., Freund, M., and Junghanss, C. Concomitant treatment of Sorafenib with dexamethasone enhances antiproliferative effects in lymphoblastic cells. Onkologie 33, Suppl. 6, Abs. P796. 2010. (Abstract)

  24. Sezer, O., Jakob, C., Aldaoud, A., Schwarzer, A., Maintz, C., Kropff, M., Blumenstengel, K., Mittermüller, J., Aulitzky, W., Wolf, H., Duerk, H., Cordes, H. J., Beck, C., Einsele, H., Schmidt, K., Friedrichs, U., Haus, U., and Freund, M. Zoledronic Acid Therapy Versus Control in Patients with Multiple Myeloma in Stage I (Durie & Salmon): Results of a Phase III Study of the "Deutsche Studiengruppe Multiples Myelom (DSMM)" and "Ostdeutsche Studiengruppe Haematologie und Onkologie (OSHO)". EHA 2010 #998 . 2010. (Abstract)

  25. Sezer, O., Jakob, C., Aldaoud, A., Schwarzer, A., Maintz, C., Kropff, M., Blumenstengel, K., Mittermüller, J., Aulitzky, W., Wolf, H., Duerk, H., Cordes, H., Beck, C., Einsele, H., Schmidt, K., Friedrichs, U., Haus, U., Freund, M., and DSMM and OSHO. Zoledronic acid therapy versus control in patients with Multiple Myeloma in stage I (Durie & Salmon): Results of a phase III study of the "Deutsche Studiengruppe Multiples Myelom (DSMM)" and "Ostdeutsche Studiengruppe Haematologie und Onkologie (OSHO)". Onkologie 33, Suppl. 6, Abs. V347. 2010. (Abstract)

  26. Wandt, H., Schaefer-Eckart, K., Pilz, B., Thalheimer, M., Ho, A., Schaich, M., Kaufmann, M., Aulitzky, W., Haenel, M., Herbst, R., Doelken, G., Klenner, A., Freund, M., Junghanss, C., and Ehninger, G. Experience with a therapeutic platelet transfusion strategy in patients with acute myeloid leukemia: final results of a randomized multicenter study
    comparing a prophylactic with a therapeutic transfusion strategy. Onkologie 33, Suppl. 6, Abs. V28. 2010. (Abstract)

  27. Wittke, C., Prall, F., Jost, K., Jeske, S., Freund, M., and Kahl, C. Bone pain, leftward shift in peripheral blood and elevated liver encymes: A case report. Onkologie 33, Suppl. 6, Abs. P533. 2010. (Abstract)

  28. Xun, X., Stockhammer, F., Mani, J., Schmitt, A., Casalegno-Garduno, R., Freund, M., and Schmitt, M. Functional dendritic cells can be generated from the peripheral blood of patients with glioblastoma even during treatment with temozolomide. Onkologie 33, Suppl. 6, Abs. P913. 2010. (Abstract)
     

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